The Healing Cycle and the Cell Danger Response are the subjects of  presentations by Dr Robert Naviaux at the Mindd International Forum 2019

Dr Robert Naviaux will present a Public Education Class at the Mindd International Forum 2019. His research and clinical experience have led to breakthroughs in understanding how healing occurs. Here are some highlights of his background research and clinical expertise that contribute to his Masterclass at the forum.

Healing is Essential to Multicellular Life

Without healing, multicellular life on Earth would not exist. Without healing, one injury predisposes to another, leading to disability, chronic disease, accelerated aging, and death. Over 60% of adults and 30% of children and teens (United States data) now live with a chronic illness. Advances in mass spectrometry and metabolomics have given scientists a new lens for studying health and disease.

Metabolic Signalling Abnormalities Block Healing

Dr Naviaux has studied the healing cycle in metabolic terms and reframes the pathophysiology of chronic illness as the result of metabolic signaling abnormalities that block healing and cause the normal stages of the cell danger response (CDR) to persist abnormally.

Reframing the Pathogenesis of Chronic Illness

Once an injury occurs, active progress through the stages of healing is driven by sequential changes in cellular bioenergetics and the disposition of oxygen and carbon skeletons used for fuel, signalling, defence, repair, and recovery. Over 100 chronic illnesses can be organised into three persistent stages of the CDR. Targetable chemosensory G-proteins coupled with ionotropic receptors are found to regulate the CDR and healing. Metabokines are signalling molecules derived from metabolism that regulate these receptors.

A Systems Problem Maintains Disease

Reframing the pathogenesis of chronic illness in this way can now be seen as a systems problem that maintains disease, rather than focusing on remote trigger(s) that caused the initial injury.

Dr Naviaux has recently focused new research on novel signalling therapies to unblock the healing cycle and restore health when other approaches have failed.

Molecular Stages of the Healing Cycle

Interruptions in the molecular stages of the healing cycle may be at the root of many complex, chronic illnesses. Three stages of the cell danger response comprise the healing cycle. These stages are triggered by stress or injury and controlled by changes in mitochondrial function and metabolism.

When a stage of the healing cycle cannot be completed, dysfunctional cells accumulate that contain developmentally inappropriate forms of mitochondria, organ function is compromised, and chronic illness results.


health and healing cycles cell danger response

A metabolic model of the health and healing cycles. Health is a dynamic process that requires regular cycling of wakeful activity and restorative sleep.

The Promise of a New Approach to Treatment

Unblocking therapies directed at stimulating the completion of the healing cycle by regulating metabokine signalling hold promise as a new approach to treatment.

Prevention and treatment of chronic illness require distinctly different, but complementary approaches. New cases of chronic illness can be prevented by reducing the environmental risks that trigger the damage cycle of the CDR, and by promoting:

  • Exercise
  • Nutritional improvement
  • Lifestyle changes

These promote resilience and maintain the health cycle.

Understanding Triggers that Interrupt Healing

Once illness has occurred in a given patient, the opportunity for prevention is lost, and a perfect storm of multiple triggers can usually be identified. Many triggers can be remote in time and no longer present.

Once any remaining triggers have been identified and removed, and any symptoms or primed sensitivities caused by the metabolic memory of those triggers have been treated, a new approach to treatment is required to improve the chances of completing the healing cycle and achieving a full recovery.

Dr Naviaux is researching how to focus away from the initial causes of illness, and towards the metabolic factors and signalling pathways that maintain chronic illness by blocking progress through the healing cycle.

Forum Class: Mitochondria, Autism, and the Cell Danger Response

Dr Robert NaviauxDr Naviaux will present an Integrative Healthcare Class at the Mindd International Forum on Mitochondria, Autism, and the Cell Danger Response.