with Drs Elizabeth Mumper, Nancy O’Hara and Robert Naviaux
Train with World Class Clinicians
Dr Robert Naviaux, MD, PhD
Mitochondrial & Metabolic Disease Expert
Dr. Robert Naviaux, MD, PhD is the founder and co-director of the Mitochondrial and Metabolic Disease Center (MMDC), and Professor of Medicine, Pediatrics, Pathology, and Genetics at UCSD, where he directs a core laboratory for metabolomics.
He is the co-founder and a former president of the Mitochondrial Medicine Society (MMS), and a founding associate editor of the journal Mitochondrion. He is an internationally known expert in human genetics, inborn errors of metabolism, metabolomics, and mitochondrial medicine.
Dr. Naviaux is the discoverer of the cause of Alpers syndrome—the oldest Mendelian form of mitochondrial disease—and the developer of the first DNA test to diagnose it. His lab also discovered the first mitochondrial DNA (mtDNA) mutations that cause genetic forms of autism and the metabolic features of the cell danger response (CDR). He directed the first FDA-approved clinical trial to study the safety and efficacy of the antipurinergic drug suramin as a new treatment for autism spectrum disorder (ASD).
His lab has developed methods in metabolomics and environmental toxicology that have show many complex chronic disorders like ASD and chronic fatigue syndrome (ME/CFS) have a metabolic signature that can be used in diagnosis and lead to fresh insights to treatment. Information about Naviaux Lab research can be found on the web at: naviauxlab.ucsd.edu. Dr. Naviaux’s publications have been cited over 6000 times.
Dr Robert Naviaux, MD, PhD
The Cell Danger Response, Healing Cycle & Chronic Disease
Medical treatments that have proven successful for acute diseases like infections, poisonings, and physical injuries have proven ineffective in chronic disorders ranging from autism to chronic fatigue syndrome, and from ALS and Lupus to Alzheimer dementia. Dr Naviaux presents a new model that reframes the pathogenesis of chronic disease as a failure to complete the molecular stages of the healing cycle. Three stages of the cell danger response (CDR1-3) make up the healing cycle and must be entered and exited in sequence to recover from any illness. Ultimately, the completion of the healing cycle is controlled by cross-talk between mitochondria and the nucleus. This new model leads to the radical prediction that a handful of new drugs and devices may be effective in the treatment of hundreds of chronic disorders.
ME/CFS is triggered by exposure to any of over 30 different, potentially life-threatening conditions that include certain infections, toxins, or trauma. The symptoms of ME/CFS typically persist long after the initial agent of injury has been cleared, leading to long-term disability and suffering. Metabolomic analysis of patients with ME/CFS, and several other chronic complex disorders like autism and PTSD, has led us to the conclusion that ME/CFS is a dauer-like energy conservation program that restricts cellular energy and resources as a failsafe response to environmental danger.
Dr Elizabeth Mumper
Dr Elizabeth Mumper is President and CEO of The RIMLAND Center. Her general pediatrics practice is Advocates for Children. Advocates for Families is her practice devoted to the care of children with autism and other neurodevelopmental problems.
Dr. Mumper graduated magna cum laude from Bridgewater College with a degree in General Science. She attended the Medical College of Virginia, did residency training at the University of Massachusetts and University of Virginia, and was invited to serve as Chief Resident of Pediatrics at UVA.
She spent five years in practice at F Read Hopkins Pediatrics in Lynchburg. She spent over a decade as Director of Pediatric Education at the Lynchburg Family Practice Residency Program. She maintained a clinical faculty appointment at the University of Virginia for 16 years. She served as Medical Director of the Autism Research Institute for five years.
Dr. Mumper has been honored to receive many awards over the years, including being named a Miracle Maker in Central Virginia in 1996 by the Children’s Miracle Network and Woman of the Year in Health and Sciences in 1998 by the YWCA. She was privileged to accept a national award for corporate public service at the National Press Club in Washington on behalf of the Bike Helmet Safety Campaign she co-chaired for many years. She was selected as Distinguished Alumna of the Year at her college in 2012.
Dr. Mumper has written book chapters about allergy, immunology and behavioral and developmental pediatrics published in the book “Pediatrics” published by Lippincott, Williams & Wilkins, which is a board review series book for medical students and includes many questions and answers. During the past five years, she has conducted clinical research at the Rimland Center and published five peer reviewed articles in the medical literature.
One of the joys of her current work is the opportunity to teach others about medical problems of children with autism and related disorders. She lectures nationally and internationally. She feels privileged to mentor physicians around the world. Her travels on behalf of children with autism have taken her to Australia, the Czech Republic, Denmark, Hong Kong, Italy, Japan, New Zealand, Norway, Poland, Sweden, Switzerland, Thailand, and the United Kingdom.
Dr Elizabeth Mumper, MD, FAAP, IFMCP
Alopecia, Vitiligo & Cutaneous Mastocytosis
These 3 conditions represent various aspects of immune dysregulation affecting the skin and hair. Dr. Mumper will examine the underlying pathology in each disorder and suggest innovative treatment strategies for each. Cutaneous mastocytosis has a much better prognosis if diagnosed early, but the average time from symptoms to diagnosis is about two years. Alopecia can sometimes respond to antifungal therapies or helminths. Integrative management of vitiligo can focus on healing strategies for balancing the immune system, not just on topical treatments.
How Ages and Stages Affect Migraines
Children’s ages and stages of development modify the way migraines present. At least 20 genes have been associated with migraines. After this lecture, the learner will be able to: 1) Recognize the atypical ways migraines may present in infants and children, 2. Identify potential migraine triggers in childhood and 3) Choose effective strategies to abort migraine headaches and 4) Develop strategies for decision making about migraine prophylaxis.
Unlocking the Allergic Triad (Allergic Rhinitis, Asthma, Eczema)
The prevalence of the conditions in the allergic triad has increased dramatically in the past few decades. The 3 conditions often travel together. Rather that only providing medications for each of the conditions, efforts should be made to identify underlying causes, remove environmental triggers and work towards healing underlying immune dysregulation. In so doing, clinicians can facilitate improvements in all the symptom manifestations. Special emphasis will be on enhancing the adaptive function of the gut in modulating immune balance.
Why Cerebral Folate Deficiency & Folate Antibodies are Important
A significant number of children in the autism spectrum have folate receptor binding or blocking antibodies. Identifying these children and treating them with leucovorin leads to clinical improvement in many. Children with cerebral folate deficiency are at risk for cognitive impairment, seizures, dyskinesias and ataxia. Attendees will learn how to spot cerebral folate problems clinically since early identification and treatment have been associated with improved clinical outcomes.
Humans have low levels of autoantibodies to lots of natural molecules. In animal models, if the low-level autoantibodies are depleted, the inflammation is much worse. Autoimmunity can now be understood as the redirection of adaptive mechanisms. In this lecture, we will explore several autoimmune conditions and look upstream at those conditions to explore how similar triggers can result in different manifestations of autoimmune disease in individual patients.
Dr Nancy O’Hara
Dr. Nancy O’Hara is a board certified Pediatrician. Prior to her medical career, Dr. O’Hara taught children with autism. She graduated with highest honors from Bryn Mawr College and as a member of the Alpha Omega Alpha Honor Society from the University of Pennsylvania School of Medicine.
She earned a Master’s degree in Public Health from the University of Pittsburgh. After residency, chief residency and general pediatric fellowship at the University of Pittsburgh, Dr. O’ Hara entered general private practice in 1993, and in 1998 began her consultative, integrative practice solely for children with special needs.
Since 1999 she has dedicated her functional medicine practice to the integrative and holistic care of children with chronic illness and neurodevelopmental disorders such as ADHD, PANDAS/PANS, OCD, Lyme and ASD. She is also a leader in the training of clinicians, both in the United States and abroad. Dr O’Hara is a member of the Mindd Foundation Advisory Board.
Dr Nancy O’Hara, MD, MPH, FAAP
Chronic Immune System Activation/Chronic Inflammatory Response Syndrome
When patients present with multi-system chronic symptoms that are debilitating, clinicians must consider the possibility of chronic inflammation. Chronic inflammatory responses may be triggered by biotoxins, tick bites, toxic metabolic products, extracellular ATP and cell wall fragments from molds. Laboratory evaluations can be utilized to identify genetic predispositions, the presence of chronic inflammation, and potential triggers. The path to recovery is complicated. Resources for patient education will be provided.
POTS & Dysautonomia
Postural orthostatic tachycardia syndrome is a form of orthostatic intolerance that is characterized by lightheadedness, fainting, and a rapid increase in heart rate with standing. It was named in the early 1990’s, and cases have been increasing in the decades since. Dr. O’Hara will explore the complexities of applying diagnostic criteria to patients who may vary in their clinical presentations. Treatment strategies and patient education resources will be provided.
PANS, PANDAS & Beyond
Pediatric Acute Neuropsychiatric Syndrome and Pediatric Autoimmune Neurologic Disease Associated with Strep are all too common in the offices of general practitioners today. This lecture will provide insights about potential infectious causes of sudden changes in the neuropsychiatric symptoms of children and the variety of symptoms that may be manifested. Treatment strategies are directed at the infection and the inflammation. The latest recommendations for treatment and prophylaxis will be explained.
Lyme: It is in Australia
Dr. William Osler was quoted as saying “he who knows syphilis knows medicine” and the same can be said for Lyme disease, coincidentally caused by a spirochete also. Lyme disease has multiple stages: an acute phase, an intermediate phase, and a chronic phase. The symptoms can become increasingly severe over time and include neurological symptoms and many different body systems. The differences in diagnostic criteria, standard and controversial treatment approaches, and laboratory interpretation will be discussed.
Trust Your Gut: Celiac & Non-Celiac Gluten Sensitivity
The discovery of zonulin revolutionized the way we think about how gluten affects humans. Even in patients without celiac disease, gluten temporarily disrupts the function of gap junctions in the gut. We need to cast a wide net to see which patients might have symptoms that would respond to gluten avoidance. Attendees of this lecture will learn the latest updates about progress in identifying and treating celiac disease and the expansion of gluten restriction for people without classic celiac disease.
Making the Grade: ADHD without drugs
Stimulant sales have soared in the past decade; pharmaceutical companies can market directly to the consumer in the US. Lifestyle modifications, including careful attention to sleep, exercise and nutrition, should be the first step in treating learning and attention problems. Some supplements have published evidence about their efficacy in improving symptoms of ADHD, and classroom interventions are critical for management. Learners will hear the latest research and get tools for managing ADHD & learning differences without reaching for the prescription pad.
Leah Hechtman is Director of The Natural Health and Fertility Centre, Sydney and has been in practice for over 20 years. She specialises in fertility, pregnancy and reproductive healthcare for men and women.
She specialises in fertility, pregnancy and reproductive healthcare for men and women. She has completed extensive advanced training and is currently completing her PhD through the School of Women’s and Children’s Health (Faculty of Medicine [UNSW]).
We are starting to understand how pregnancy changes the mother in unintended ways. No longer can we just put it down to the emotional links between mother and child. Foetal microchimerism describes what our children leave behind in their mothers – cells that are not their own and we know that these cells may help or harm her depending on many variables. What we are also now discovering is that Maternal microchimerism occurs as well – the maternal lioness is more than a maternal instinct – her very cells exist within her child. Synchronistically with this, our understanding of mRNA is evolving in ways we hadn’t predicted. The long held belief that mRNA was only passed down from mother to child has recently been debunked with paternal mRNA showing its presence and impact as well. What does this all mean for us as clinicians? As parents? As human beings? How can we influence these unique genetic pathways and how can we improve the health of future generations? We’ll explore some of the latest research in these fascinating areas and discuss the clinical applications to improve the health for all.
Dr Leila Masson
Dr Leila Masson is a consultant paediatrician who specialises in nutritional and environmental medicine for children’s health issues, including allergies, asthma, behaviour problems, autism spectrum disorders and ADHD. She has a busy clinic in Sydney where she sees children and mentors doctors in integrative paediatrics.
Dr Masson received her medical doctorate from the Free University of Berlin and did her paediatric specialist training at the University of California in San Francisco. She received her Master in Public Health from Harvard University and her Diploma in Tropical Medicine from the London School of Hygiene and Tropical Medicine. She is a fellow of the Australasian College of Nutritional and Environmental Medicine. Dr Masson is a board member of AIMA, the Australasian Integrative Medicine Association. She is also on the board of professional advisors of La Leche League New Zealand. Leila has worked in the US, Europe, New Zealand, and volunteered for 2 years setting up a rural clinic in Pakistan. Dr Masson lectures internationally on the subject of children’s nutrition and an integrative medicine approach to paediatric issues, including autism spectrum disorders, ADHD, allergies, recurrent infections, and autoimmune diseases. She speaks English, German, French, and Spanish.
She is the author of “Children’s Health A-Z” a parent’s guide to natural therapies for common childhood ailments.
Specific areas of interest in her practice
Integrative approach to paediatrics, including chronic diseases, developmental, and behavioural problems
Biomedical treatment for autism spectrum disorders and ADHD
Nutritional and Environmental Medicine
Allergies, asthma, and eczema
Gut health, including reflux, chronic diarrhoea, and constipation
Preventive medicine and positive parenting
Doctorate in Medicine, Freie Universität Berlin
Fellow, Royal Australasian College of Physicians
Fellow, Australian College of Nutritional and Environmental Medicine
Registered as specialist Paediatrician in Germany
Fellow of the American Academy of Pediatrics (past)
Master in Public Health, Harvard University
Diploma in Tropical Medicine and Hygiene from the London School of Hygiene and Tropical Medicine
Board Certified Lactation Consultant
Dr Leila Masson, M.D., MPH, FRACP, FACNEM, IBCLC, DTMH
The Gut-Cell Danger Response Connection
When our cells are harmed by toxins, infections, or physical injury the cell danger response is elicited to protect us and repair the damage. Dr Masson will discuss the latest research on strengthening our bodies to prevent chronic illness: Lifestyle, nutritional, and environmental interventions that promote a healthy microbiome increase our bodies’ capacity to remain healthy.
A healthy microbiome is needed for a strong immune system, well-functioning detoxification pathways, and to reduce inflammation; all of these help our cells and bodies to withstand injury and harm and to recover quickly rather than spiralling into chronic ill health.
Register Now and Transform Your Practice
2 Day Pass to CPE Approved Practitioner Training
Lunch and Snacks Provided on All 2 Days
Speakers Reception *Mindd Members Receive Free Pass
Lunch Queue Jump
Access to VIP Lounge
Exclusive Q&A with Guest Speaker
Priority Seating for Presentations
Mindd Practitioner Directory Listing *Participants who pass test administered at end of training will be listed at mindd.org