The Healing Cycle and the Cell Danger Response are the subject of two masterclasses to be presented by Dr Robert Naviaux at the Mindd International Forum 2019. His research and clinical experience have led to breakthroughs in understanding how healing occurs. Here are some highlights of his background research and clinical expertise that contribute to his Masterclasses at the forum.
Healing is Essential to Multicellular Life
Without healing, multicellular life on Earth would not exist. Without healing, one injury predisposes to another, leading to disability, chronic disease, accelerated aging, and death. Over 60% of adults and 30% of children and teens (United States data) now live with a chronic illness. Advances in mass spectrometry and metabolomics have given scientists a new lens for studying health and disease.
Metabolic Signalling Abnormalities Block Healing
Dr Naviaux has studied the healing cycle in metabolic terms and reframes the pathophysiology of chronic illness as the result of metabolic signaling abnormalities that block healing and cause the normal stages of the cell danger response (CDR) to persist abnormally.
Reframing the Pathogenesis of Chronic Illness
Once an injury occurs, active progress through the stages of healing is driven by sequential changes in cellular bioenergetics and the disposition of oxygen and carbon skeletons used for fuel, signaling, defense, repair, and recovery. Over 100 chronic illnesses can be organized into three persistent stages of the CDR. Targetable chemosensory G-proteins coupled with ionotropic receptors are found to regulate the CDR and healing. Metabokines are signaling molecules derived from metabolism that regulate these receptors.
A Systems Problem Maintains Disease
Reframing the pathogenesis of chronic illness in this way can now be seen as a systems problem that maintains disease, rather than focusing on the remote trigger(s) that caused the initial injury.
Dr Naviaux has recently focused new research on novel signaling therapies to unblock the healing cycle and restore health when other approaches have failed.
Molecular Stages of the Healing Cycle
Interruptions in the molecular stages of the healing cycle may be at the root of many complex, chronic illnesses. Three stages of the cell danger response comprise the healing cycle. These stages are triggered by stress or injury and controlled by changes in mitochondrial function and metabolism.
When a stage of the healing cycle cannot be completed, dysfunctional cells accumulate that contain developmentally inappropriate forms of mitochondria, organ function is compromised, and chronic illness results.
The Promise of a New Approach to Treatment
Unblocking therapies directed at stimulating the completion of the healing cycle by regulating metabokine signaling hold promise as a new approach to treatment.
Prevention and treatment of chronic illness require distinctly different, but complementary approaches. New cases of chronic disease can be prevented by reducing the environmental risks that trigger the damage cycle of the CDR, and by promoting nutritional and lifestyle measures that promote resilience and maintain the healing cycle.
Understanding Triggers that Interrupt Healing
Once illness has occurred in a given patient, the opportunity for prevention is lost, and a perfect storm of multiple triggers can usually be identified. Many triggers can have occurred in the distant past and no longer be present.
The first challenge is to identify and remove triggers including the metabolic memory of past triggers. Then a new approach to treatment is required to improve the chances of completing the healing cycle and achieving a full recovery.
Dr Naviaux is researching how to focus away from the initial causes of illness, and towards the metabolic factors and signaling pathways that maintain chronic illness by blocking progress through the healing cycle.
Dr Robert Naviaux will present Masterclass lectures at the Mindd International Forum:
- The Cell Danger Response, Healing Cycle & Chronic Disease
- Chronic Fatigue Syndrome Metabolomics & Future Clinical Trials
What Practitioners Will Learn from Dr. Robert Naviaux’s Masterclasses to Apply in Their Own Practice:
- The interconnected relationship between mitochondria and the nucleus in perpetuating the healing cycle and treating chronic disease
- Understanding Chronic Fatigue Syndrome in a new light: the impact of metabolomic analysis and the importance of cellular energy in unblocking the healing cycle